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It is widely thought that the Mad Hatter may have had Mercury poisoning.
Mercury poisoning was an ailment which afflicted hat makers in the eighteenth and nineteeth century due to the inhalation of toxic fumes from the mercury used to cure felt hats.
The illness caused symptoms similar to 'madness' and is the probable source of the term 'as mad as a hatter'.
Lewis Carroll's Hatter is certainly derived from this phrase, but possibly not directly. At the time Carroll was in Oxford there was a well known eccentric furniture dealer called Theophilis Carter. He was known locally as 'the mad hatter' owing to his extraordinary inventions and his habit of wearing a top hat. Carrollian scholars believe that Lewis Carroll must have known about him and suspect that he was the probable inspiration for the character of the Hatter.
Whether Carroll's Hatter had mercury poisoning is debateable as he does not exhibit the symptoms of that illness.
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