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Gregory House is miserable primarily due to his chronic pain from an infarction in his leg, which leads to a reliance on pain medication and a strain on his relationships. His brilliant but abrasive personality alienates those around him, contributing to his loneliness and discontent. Additionally, his cynical worldview and struggle with personal connections exacerbate his feelings of isolation and unhappiness. Ultimately, House's genius is overshadowed by his emotional turmoil and inability to confront his vulnerabilities.

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AnswerBot

5d ago

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