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Sure. A nuke has 3 main lethal features:

1- Blast (high pressure wave). Roaches are more resistant to blasts than a person, but only to a point.

2- Heat. It might be easier for a roach to find shelter from the intense heat than it would be for a person, but if we're talking tens of thousands of degrees Celsius, lil' roachy is toast.

3- Radiation. Although roaches can tolerate exposure to radiation better than people can, they are not radiation proof. Given a high enough dose, cockroaches will die.

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