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Nuclear size and shape are determined by a number of factors.

Size: Amount of genetic material, fluid, proteins and byproducts of the transcription process.

Shape: Most nuclei are "anchored" in the cell by microtubules that are coordinated by the centrosomes. This internal structure works a lot like steel beams when constructing home or other buildings.

Position: Is also determined by the relationship between motor proteins that are attached to the nuclear envelope and the microtubules.

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