by the Hypothalamic-pituitary portal system
The hypothalamus sends releasing hormones to the pituitary gland down through a salk of tissue called the infundibulum. It tells it which hormones to make and when to make them.
TRH stands for thyrotropin-releasing hormone. It is a hormone produced by the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) from the pituitary gland, which in turn regulates the release of thyroid hormones from the thyroid gland.
The hypothalamus sends the TRH hormone via some capillaries. Now, these are very special capillaries, yes they connect to the circulation, as capillaries do. However, these capillaries are different in that they act as a portal. In fact, they have a name for them too, called the hypothalamo-pituitary portal vessels. Basically how they work is, blood coming from the heart first integrates into the hypothalamus, and upon the exocytosis type of release from the nuclei within the hypothalamus that contain the hormones (talking about in this way the nuclui that produce the homones release those hormones directly into capillaries via a similar manner as how neurotransmitters are released into a synapse). Once the hormones are released into the capillaries of the hypothalamus-pituitary vessels, they travel down and into the anterior pituitary. Where they are actively transported into the cells of the anterior pituitary (notice nothing about the posterior pituitary, because that functions in a different manner).
Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) from the pituitary gland. TSH then acts on the thyroid gland to stimulate the production and release of thyroid hormones, which regulate metabolism and energy balance in the body.
TSH is inhibited by feedback inhibition exerted by the thyroid hormones on the anterior pituitary and hypothalamus and by GHIH.
An example of a hormone that influences an endocrine gland other than its source is thyrotropin-releasing hormone (TRH). TRH is released by the hypothalamus and acts on the anterior pituitary gland to stimulate the release of thyroid-stimulating hormone (TSH), which in turn acts on the thyroid gland to regulate thyroid hormone production.
There is a part of the brain called the hypothalamus which is next to the pituitary. When you have not enough Thyroxine (T4) your hypothalamus makes TRH which tells the pituitary to make Thyroid stimulating hormone (TSH). TSH as in the name stimulates the thyroid gland in the neck to make more Thyroxine.
Like other hormones of the anterior pituitary (adenohypophysis), TSH is stimulated by a releasing hormone produced in the hypothalamus. This releasing hormone, TRH (thyrotropin releasing hormone) travels down the pituitary stalk and stimulates the thyrotrope cells there, via the portal circulation of the pituitary.
growth hormone-releasing hormone (GHRH)
The hypothalamus gland secretes releasing hormones, such as Gonadotropin-releasing hormone (GnRH), Corticotropin-releasing hormone (CRH), and Growth hormone-releasing hormone (GHRH), that stimulate the release of hormones from the pituitary gland.
Is a hormone secreted bx thyroid gland important in maintaing calcium and phosphate balance of the body,normal development of neurons,maintaining metabolic rate,important in growth of infants.
Thyroid stimulating Harmones amino acids derivatives, these harmones control and regulate the body metabolism. 60-70% thermogenesis of the body is done by thyroid harmones. jahangir.ajiz@yahoo.com