Most of the time, the death is caused by respiratory depression. Opiates (pain killers) cause central nervous system (CNS) depression, which, if depressed enough, starts to shut down the respiratory center within the brain stem = you stop breathing.
GABA agonists (Ambien, benzodiazepines and other sedating meds) cause CNS depression as well. But some, like benzos, also have skeletal muscle relaxant properties as well that can cause the diaphragm (a skeletal muscle), and other breathing muscles, to be unable to contract enough to properly move air in and out of the lungs.
Another problem is not overdose per se, but a combination of prescription medications and alcohol. The issue is alcohol is a CNS depressant as well. When you combine alcohol with opiates and/or sedatives, you amplify the risk of respiratory depression.
I hope this answers your question.
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The pancreas
The Scientific Method
250/person
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The person asked, "What secrets are you hiding?"
If they were secrets, we wouldn't know about them. However, I'm sure every person has secrets.
blunt
The main character in The Black Book of Secrets is Ludlow Fitch.
the secrets that a person would need to know about in order to answer your question they're still secrets, so nobody knows, mate!
a snitch
Secrets of the Jedi has 203 pages.
Secrets in the Fire has 168 pages.
Secrets of the Clans has 176 pages.
Secrets of the Morning has 405 pages.
The Secrets of Vesuvius has 224 pages.
Summer of Secrets has 176 pages.