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Occasionally, estimation must be used to account for objects, like body cells or other very small things.

In measurement, techincally, everything is an estimation -- unless it is an integer. How long is the block? Do you measure it to the neaest inch, tenth inch, thousandths of an inch? Reminds me of the question: How long is the coast line of England??

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Q: When is it appropriate to rely on estimation?
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