It's about a 5 hour drive, or less, from West Palm to Key West. Start off going south on the Florida Turnpike until it ends and then get on US1. Take US1 south until it ends and you will be in down town Key West. It's that easy!!!
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Key West Key West
It is an island but you can drive there because the military built roads to Key West. Highway US1 - Mile 0 is in Key West and that is why you see all the merchandise with Mile 0 on it.
It's 265 miles from Key West FL to Stuart FL
boca shica key
231 miles
about 230 miles
The Keys are 120 miles long. West Palm to Key West is 231 miles.
About 233 miles
Greyhound
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4 1/2 hours
7 or 8 hours. depending on traffic
Orlando, naples, Miami, panama city beach, key west, key largo, st petersburg, Tampa, west palm beach, Pensacola
The halfway point between New Smyrna Beach and Key West would be somewhere in West Palm Beach. The exact town I do not know but this is your midpoint.
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It is 231 miles according to Google Maps.