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317 miles taking this route:

  1. Take I-24 EAST from Clarksville to I-40 EAST via TN-155 - BRILEY PKWY to bypass downtown Nashville (EXIT 43 off I-24 to get onto TN-155 - BRILEY PKWY, SECOND RIGHT onto TN-155 - BRILEY PKWY EAST ; EXIT 6A off TN-155 - BRILEY PKWY to get onto I-40 EAST to KNOXVILLE).
  2. Take I-40 EAST across to I-81 NORTH to BRISTOL at EXIT 421. To bypass downtown KNOXVILLE, take I-640 EAST (EXIT 385 off I-40).
  3. Take I-81 NORTH to I-26 WEST to KINGSPORT at EXIT 57B.
  4. Take I-26 WEST to Kingsport.
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