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590 miles taking this route:

  1. Take U.S. 501 NORTH (towards CONWAY), from Myrtle Beach, to U.S. 76 WEST to FLORENCE (TO I-20 WEST), via U.S. 501 BUS./SC-576 around Marion.
  2. Take U.S. 76 WEST to I-20 WEST to COLUMBIA, via SC-327 NORTH and I-95 SOUTH (EXIT 160B off I-95) to bypass FLORENCE.
  3. Take I-20 WEST to I-26 WEST to SPARTANBURG off EXIT 46B.
  4. Take I-26 WEST to I-40 WEST to KNOXVILLE off EXIT 31B.
  5. Take I-40 WEST to Nashville.
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12y ago

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