The shortest driving distance is 510 miles.
366 miles taking this route:Take I-95 SOUTH from St. George down to I-4 WEST to ORLANDO at EXIT 260B in Daytona Beach, FLORIDA.Take I-4 WEST to ORLANDO.
Charleston, SC, is approximately 300 miles northwest of Gainesville, FL. The drive between the two cities typically takes around 5-6 hours depending on traffic and route taken.
65 miles down I-26 EAST, about an hours drive.
The driving distance from Tarpon Springs FL to Hilton Head Island SC is 373 miles per Map Quest. The driving time per Map Quest is 6 hours and 8 minutes.
344 miles or 553.5 Kilometers
441 miles
Spartanburg, SC
It is 373.84 miles according to MapQuest.
It is 484.12 miles according to MapQuest.
556 mi or about a 9 hour drive.
There are 57 miles between Spartanburg, SC, and Asheville, NC (as the bird flies).
It is 500.04 miles according to MapQuest.
Spartanburg, SC
25 miles down I-85 SOUTH.
100 miles
It is 238 miles according to Google Maps.
It's about 530 miles and would take around 8 hours to drive.