The teacher could not teach her class because there was a lot of noise outside that was a very big disruption.
The hurricane caused a major disruption in offshore drilling. Ionizing radiation can cause the disruption of cells within living organisms.
I had to talk to him about his work.
Describe what is your " work ethic"
edit your work
I was inpress by your work.
I work very hard.
It depends how you use it. If you use it after something it can be correct. But being in a sentence by itself isn't correct.
Example sentence - His missionary work was great.
She work erratically.
i will complete my work
Comence with your work men!
There was flexibility in his work schedule.