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There are many drug manufacturers world wide who are competing for the flu vaccine business. Each makes their own version. For example, some contain different preservatives and some are made with "live" virus particles (in the US, the nasal sprays) and others with "dead" virus particles (the types for injection).

Each manufacturer also may make different formulations of the vaccine to be administered in different ways and to different people. Those who have suppression of the immune system can not take the live virus vaccines, for example. Some have contraindications for people of different ages or medical history or for those with allergy to the specific preservatives used.

Each flu season in the US we have a new recommendation from epidemiologists for what virus particles are expected to be causing the flu in our location in that season which determines which virus subtypes and strains will be included as the antigen in the vaccine. There are three of these selected each year to be put into the one annual vaccine. This is why there is a new vaccine formulation each season adjusted to include the appropriate types of flu viruses that we need to be protected from that year.

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12y ago

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