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Yes. In time - especially if you are not religious about taking the right doses of the right drugs at the right times - HIV can develop resistance to the drugs used to treat HIV. This is one of the reasons why HIV-positive patients receiving treatment are advised to have regular blood tests - the blood tests enable doctors to monitor the continued effectiveness of the treatment. If you develop resistance to one or more of the drugs you are being treated with, then other drugs will be substituted in to your treatment regimen to bring the infection back under control. Taking your drugs in exactly the manner prescribed - in the right dose, at the same time, EVERY single day, with or without food - ensures that the right levels of the drugs are maintained at all times. Doing this is the single most important thing you can do to keep the virus firmly under control and avoid developing resistance to your drugs .. it is generally when the levels of the drugs fall below therapeutic levels that the virus gets the opportunity to mutate and develop resistance.

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