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For sure, if the surgical option is chosen to treat hyperthyroidism (Graves' disease), an overly aggressive thyroid ablation will lead to accidentally removing too many of the (usually) six parathyroid glands embedded within the thyroid tissue. Am currently researching the role of the pituitary feedback loop in generating hypocalcemia in the untreated hyperthyroid state (other than the incredibly rare event of a TSH-secreting pituitary adenoma).

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What causes nerve irritability and painful muscle cramps from having hypocalcemia?

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The prognosis for correcting hypocalcemia is excellent. However, the eye damage that may result from chronic hypocalcemia cannot be reversed.


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Citrate in blood binds to calcium ions, forming complexes that are not available for biological functions. This decreases the amount of free calcium in the blood, leading to hypocalcemia. Additionally, citrate can chelate calcium in the blood, further reducing the level of ionized calcium available for use in blood clotting and nerve function.


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What are the major symptoms of hyperthyroidism?

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