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Mu opiates can cause manic or hypomanic reactions in patients with Bipolar disorder - see

Mood-Elevating Effects of Opioid Analgesics in Patients With Bipolar DisorderCharles B. Schaffer; Thomas E. Nordahl; Linda C. Schaffer; Jeanne Howe

The Journal of Neuropsychiatry and Clinical Neurosciences 2007;19:449-452.

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