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While it is possible it may rarely help some people, Zoloft is not widely used to prevent migraine. Sertraline, or Zoloft, is an SSRI. Medications in the SSRI category are used to prevent migraines, however - Prozac is the most often used. Tricyclic antidepessants, which are older than SSRIs and also work with serotonin have proven more effective at preventing migraine. SNRIs, such as Cymbalta and Effexor, have also been proven effective.

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