Can women be hemopheliacs

Answer 1

Yes, women can have hemophilia. Depending on the definition of hemophilia you follow, there are two main ways in wich females can have hemophilia.

The first way we'll look at is accepted by everyone and there i no reason for debate whatsoever. This is when a female has a mutation for hemophilia on both of her X chromosomes. This is extremely rare. For a female to have mutations on both X chromosomes, she would have to have either;

A. inherited the mutation from both parents (meaning that her father was a hemophiliac and her mother carried the gene) or;

B. inherited the mutation from one parent at the same time she had a spontaneous mutation occur on the other X chromosome, or;

C. Had spontaneous mutations to both X chromosomes at the same time.

The next way a female can have hemophilia is a subject of some debate (wich at least to me seams silly as there should be no debate at all). Females with a mutation on a single X chromosome often demonstrate bleeding problems and Clotting Factor Protein levels like those seen in non-controversial cases of hemophilia. In recent years doctors have begun recognizing that these females with low clotting factor levels (historically called symptomatic carriers) need to be treated in the same way as any other hemophiliac with equivalent factor levels. This new approach puts more weight on the phenotypic results rather than the genotypic.