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Most ink in ballpoint pens is nontoxic however bottled ink may contain carcinogenic solvents such as xylene. Permanent markers often contain industrial solvents such as n-butanol, cresol and diacetone alcohol which can cause damage to DNA, kidneys, liver and brain tissue if they come in contact with the skin and subsequently enter the bloodstream. So yes through extended contact with xylene based inks you could develop cancer.

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