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If you mean, "can you live without your large intestine?" then yes, you can. One must wear a Colostomy bag to collect the waste that leaves the small intestine. The large intestine also plays a small role in reabsorbing water and ions, so one would have to make sure they are not getting dehydrated or experiencing symptoms of low ion concentrations.

If you mean "with only small intestine -- no stomach, etc.", then no, you cannot.

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