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extreme traumatic stress- War neurosis- battle shock- for example- possibly civil angle such as massive trauma from witnessing horrific crime, fire or again, accident- which could involve head injuries- also such things as terrorism and political variations ( as the girl from Russia- who was always going blank when pressed on what happened in the fateful night in the Basement in Ekaterinberg! There are many causes.
There are many reasons to get amnesia, the primary reason is traumatic stress, some times old age can also lead to amnesia.

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Can you get amnesia by locking yourself in a room for 2 days without food or water?

It actually depends on what you do in the room. If you just sit there, or do other exercises and whatnot that doesn't harm yourself, then you can't get amnesia. If you bang your head against the wall, ram your head into a wall, or beat yourself over the head with a stick or other object, then you could possibly develop amnesia. Amnesia derives from damage to parts of the brain, which often is affecting the limbic system, which is the part of the brain that controls memory recall. Without food or water, you might just get dizzy, or faint, but not develop amnesia, since amnesia derives from damage to specific parts of the brain (the parts that control memory function).


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