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A prednisolone burst and taper (e.g. Medrol dose pak), for treatment of an allergic reaction or respiratory illness, is reasonable to take with any antidepressant - on a short term basis. The risk of long-term steroid use is that of depression, Cushing's syndrome and quite a few other side effects.

In the short-term, therapeutic steroid use with antidepressants is generally well-tolerated. However, if increased anxiety or depression (or any psychotic features such as paranoia, hallucinations) occur, then notifying the prescribing physician, as soon as possible, is of the utmost importance.

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