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Yes, there are several cases in the medical literature where a person has locked in syndrome for a short while and then spontaneously recovers. Typically, if locked in syndrome occurred due to a vascular problem (eg stroke) you either make a dramatic recovery within the first two weeks, or you remain in locked in syndrome indefinitely. In contrast, if the cause was non-vascular (eg a head injury) you typically see more intermediate recovery months afterwards. Overall, the prognosis is better for non-vascular locked in syndrome.

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