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If gangliosides were removed from the surface of target cells, cholera toxin would be unable to bind effectively to these cells. This would prevent the internalization of the toxin and its subsequent activation of adenylate cyclase, leading to a decrease in cAMP levels. Consequently, the disruption of ion transport and fluid secretion that characterizes cholera would be significantly diminished, likely reducing the severity of the disease. Overall, the absence of gangliosides would inhibit the pathogenic effects of cholera toxin.

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1w ago

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