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Erythrocytes are larger than leukocytes. Erythrocytes have no nucleus while leukocytes have nucleus. Leukocytes remove and/ or destroys things that are considered "abnormal" in the body while erythrocytes carry oxygen to all body cells. Leukocytes are large round cells that do not contain hemoglobin while erythrocytes contain hemoglobin, are shaped as biconcave disks that bend, flex travel through narrow blood vessels and have a large surface to volume ratio.

Erythrocytes and leukocytes are both classified as formed elements (lower layer). They both are main components of the body are necessary for the body to function properly.

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