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[From Genetics of prostate cancer part of the National Cancer Institute website]

As with breast and colon cancer, familial clustering of prostate cancer has been reported frequently. From 5% to 10% of prostate cancer cases are believed to be due primarily to high-risk inherited genetic factors or prostate cancer susceptibility genes. Results from several large case-control studies and cohort studies representing various populations suggest that family history is a major risk factor in prostate cancer. A family history of a brother or father with prostate cancer increases the risk of prostate cancer by 2-fold to 3-fold, and the risk is inversely related to the age of the affected relative.

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