yes they do
The 6 amino acid in the hemoglobin beta chain is different than that of a normal hemoglobin protein. This causes the hemoglobin protein to change shape, and if a protein changes shape it also changes function. These proteins have more hydrophobic areas that link together to form chains. It is these chains that causes the blood cell to become sickle in shape. These blood cells are hard and more sharp on these edges, while normal blood cells appear as if they a soft dougnuts. When normal blood cells travel through blood vessels they sometimes bounce off the vessel walls, this is also true for sickle cells but instead of bouncing off they become inbedded in the vessel wall. over time other sickle cells pile up on the original sickle cell eventually blocking the vessel completely.
Vitamin c
Thromboplastin, also known as tissue factor, is produced by subendothelial cells in blood vessel walls and by blood cells called monocytes and macrophages. Upon injury to a blood vessel, thromboplastin is exposed and initiates the extrinsic pathway of blood coagulation.
Blood flow in the center of a large vessel is faster because the walls of the blood vessel may have a buildup of cholesterol on them.
The smallest type of blood vessel is the capillary. Its walls are one cell thick and permeable, for substances to transfer out of the capillary and into the cells (and vice versa).
Yes, the capillaries are the smallest kind of blood vessel, that facilitate the movement of substances (like oxygen and glucose) in and out of the blood through their very thin walls.
a possible way it can kill you is from a simple blood clot. If the sickle shaped blood cells that formed into clumps stick to the walls of the blood vessels, blood flow will be blocked and the lack of blood circulation can cause a blood clot. If that blood clot so happens to follow the blood stream into your heart... YOU WILL DIE.
Veins
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Platelets are the type of blood cells responsible for helping with blood clotting. They form a plug at the site of a wound to stop bleeding by adhering to the damaged blood vessel walls and releasing chemicals that promote clotting.
When white blood cells leave the capillaries, this process is called diapedesis or extravasation. It allows white blood cells to move from the blood vessel into the surrounding tissues to reach sites of infection or inflammation.
When the blood vessels become inflamed, scarring, thickening of the vessel walls, and narrowing of the vessel caliber decrease the amount of blood flow