Without B12, red blood cell production is greatly reduced
Red blood cells
Vitamin B12 is crucial for the production of red blood cells in the body. It helps in the formation of healthy red blood cells, which are responsible for carrying oxygen throughout the body. Without enough vitamin B12, red blood cell production can be impaired, leading to anemia and other health issues.
Enlarged red blood cells can be caused by both inflammation and B12 deficiency. Inflammation can disrupt the normal process of red blood cell production in the bone marrow, leading to larger cells. On the other hand, B12 deficiency can impair DNA synthesis in red blood cell production, resulting in larger cells known as megaloblasts.
Vitamin B12 primarily functions in cell regeneration and the synthesis of red blood cells. It plays a crucial role in DNA production, which is essential for new cell formation, and also helps in the production of red blood cells in the bone marrow. Deficiency in vitamin B12 can lead to anemia and impaired cell regeneration.
Vitamin B12 plays a crucial role in erythropoiesis by supporting the maturation of red blood cells in the bone marrow. It is involved in the synthesis of DNA, which is essential for the production of red blood cells. A deficiency in vitamin B12 can lead to impaired erythropoiesis and result in a type of anemia known as megaloblastic anemia.
Yes, a high dose of B12 can affect it. I had irregular menstruation symptoms, sometimes half a year and longer without menstruating, and -always- after a high dose of B12 (oral, not injected) the menstruation started a few hours later. This is probably caused by something called intrinsic factor - stomach cells that produce intrinsic factor are destroyed or missing, without them you can't absorb B12, no matter if your diet includes more or less B12. Only very high doses may get through (or injected B12), these high doses are not present in ANY food. As soon as your B12 storage is emptied (B12 can be stored in the body for 5-12 years or so), symptoms of B12 deficiency occur, it leads to pernicious anaemia, means that the production of red blood cells is defect, blood cells won't divide any more, you start to have less, but huge red blood cells, since they are not divided. In this environment your menstruation probably stops due to the deficiency of healthy red blood cells. My conclusion is that a very high dose of B12 probably leads to a sudden rush of blood cells, and this may start the menstruation, even after it has stopped for a very long time. Don't forget to supplement iron, and folic acid together with B12 - since the production of blood cells depends on them. For that reason a high dose of B12 may lead to an iron and folic acid deficiency, if not supplemented, they are all used up to build the new blood cells.
Vitamin B12
They are cofactors in the synthesis of DNA so their function resides in the reproduction and maduration of blood cells. B6 and B12 deficit can lead to anemia, leukopenia, thrombocytopenia or pancytopenia, that is low red blood cells, low white blood cells, low platelets or low blood cells in general.
B12/folate, Vitamin C, Copper,
A deficiency in folate or vitamin B12 can lead to macrocytic anemia because these nutrients are essential for the production of red blood cells. Without enough folate or vitamin B12, the red blood cells become larger than normal (macrocytic) and are unable to function properly, leading to anemia.
You can become anemic if you have a B12 deficiency. The vitamin is needed to make hemoglobin for your red blood cells.
LDH enzyme (subtype 4H) is very abundant in red blood cells and heart muscle. In vit B12 deficiency there is high destruction of red cells in the bone marrow and in the blood vessels. As RBCs ruptures they release their inner content into the blood stream. So that's how LDH goes up in the blood.