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Really, really good heroin makes you itchy all over. As soon as you smoke a couple of hits of really good heroin, your whole body starts itching all over. This is true of other strong opiates, too (like morphine and oxycodone).

The reason is that heroin releases histamines in your body (histamines are what produce physiological symptoms like a runny nose, sneezing, etc., in order to flush out bacteria and viruses. They are your body's response to, and defense against, invading bacteria and viruses.) Basically, heroin releases these histamines, which trick your body into thinking it's itchy.

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15y ago

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