Interesting question but this is a character set in a deserted area. In the case with this individual I would say that he does not have AS. People with AS usu. have a normal to above normal intelligence (oddly enough score lower in math than normal). Wile E Coyote is silent (like those with AS), creative (common for those with AS) and intelligent (believed to be a sign of AS) however this cartoon is designed for quiet individuals such as Roadrunner, who may score higher for AS than Coyote as he usu. avoids him (people with AS are normally very independent and will even avoid social events due to being socially awkward).
Wile E. Coyote, Super Genius.
The two have never had a dialogue with each other . Wile E. Coyote does talk in the episode with Bugs Bunny in "Operation : Rabbit" where Wile E. Coyote refers to himself as "Wile E. Coyote - super genius" when he hands Bugs Bunny his calling card . The Road Runner is only known for his "Beep Beep" vocalizations .
It is Wile E. Coyote.
Wile E. Coyote is an original creation of Chuck Jones .
Wile E. is a coyote and Road Runner is a well a Roadrunner
Wile E. Coyote Canyon Blaster was created in 2004.
Wile E. Coyote's Grand Canyon Blaster was created in 2001.
. . . patient .
Sam the Sheepdog & Wile E. Coyote
Wile E. Coyote .
Wile E. Coyote .
the road runner! :)