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I think that it can. I've been off and on doxycycline for about one year. At first, there was no problem. However, the last couple of rounds were unreal. I thought I was diabetic. I was thirsty all the time, and couldn't sleep more than three or four hours without having to get up to urinate. I often slept only four hours, then woke up for four hours and finally finished my other four hours of sleep. When I ate no sugar, only ate moderate amounts of slow burning carbs like brown rice and pumpernickle bread like diabetics have to do, the problem stopped. I'm convinced it was the doxycycline because the problem has stopped now that I am off of it.

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