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Rh disease primarily affects the second child if the first child was Rh-positive and the mother is Rh-negative. During the first pregnancy, the mother may develop antibodies against Rh-positive blood if fetal blood cells mix with hers, but this usually doesn't harm the first child. In subsequent pregnancies, these antibodies can cross the placenta and attack the red blood cells of an Rh-positive second child, potentially leading to severe complications. Therefore, while the first child is typically unaffected, the second child may be at risk if proper medical interventions are not taken.

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3w ago

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