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  • In many instances, people have elevated uric acid levels for hereditary reasons.
  • Diet may be a factor. High intake of dietary purine as well as fructose (and table sugar which is roughly 50% fructose) can cause increased levels of uric acid.
  • Serum uric acid can be elevated due to reduced excretion by the kidneys.
  • Fasting or rapid weight loss can temporarily elevate uric acid levels.
  • Iron (Fe) activates xanthine oxidase (XO) and copper (Cu) deactivates it, so as men accumulate Fe with age (ferritin levels rise above 45 ng/dl) and Cu levels decline as testosterone levels drop with age (testosterone increases Cu half life), eventually the high Fe/Cu results in more active XO and higher urate levels. Excess Fe can be eliminated through phlebotomy (blood donation) and low Cu can be corrected through daily intake of 2 mg Cu per day, reducing urate levels.

( Stress is not mentioned as a cause of uric acid increase.)

Source: Wilkipedia

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