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The story of how blood clots, is the story of rapid-fire reactions. The first step in the chain is some kind of injury to a blood vessel, that makes a rough spot in its lining. Normally the lining of a blood vessel is smooth.

Almost immediately, damaged tissue cells in the injured blood vessel wall release certain clotting factors into the plasma. The factors rapidly react with other factors already present into the plasma to form prothrombin activator. At the same time this is happening, platlets become sticky at the point of injury and soon acculmalate near the opening in the broken blood vessel, formimg a soft, temporary platlet plug. as the platlets accumulate, they release addditonal clotting factors, formimg even more prothrombin activator.

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15y ago

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