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First the structure of a lymph node... we have the cortex, paracortex and the medulla. It is made mainly of recticular cells, then lymphocytes and macrophage.

So you have APCs presenting the antigen which enter lymph node via HEV, basically post-capillary venous swelling made of simple cuboidal cells. These allows things in blood to enter the lymph node. Then after that you have the APC interacting with B cells in the cortex and the T helper cells in paracortex.

Both B and T cells get stimulated.

B cells can either stay in cortex to form secondary follicles / germinal center or migrate to medullary cord to become plasma cells and secrete antibodies.

The function of germinal center is to increase antibody affinity, isotope change (change classes) and differentiation and proliferation.

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