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Lymphatics is the vascular system dedicated to drainage and filtration of interstitial fluid, carriage of fats after digestion, and interconnection of the lymphatic nodes. Therefore, when pathogens enter a tissue (e.g. through a cut), local acute inflammation (as part of the innate immune response) causes increased lymphatic permeability and enable some of the particles to be carried from the site of infection to a lymph node via the lymphatic system. A lymph node is an aggregation of lymphoid cells (T cells and B cells) in the periphery and initiates the adaptive immune response, which is more systematic and clears the infection more effectively.

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