The hypothalamic-pituitary-gonadal axis (also HPG axis) is referring to the effects of the hypothalamus, pituitary gland, and gonads as if these individual endocrine glands were a single entity as a whole. Because these glands often behave in cooperation, physiologists and endocrinologists find it convenient and descriptive to speak of them as a single system.
The hypothalamic-pituitary-gonadal axis is a critical part in the development and regulation of a number of the body's systems, such as the reproductive, and immune systems. Fluctuations in the hormones cause changes in the hormones produced by each gland and have various widespread and local effects on the body. This axis controls development, reproduction, and aging in animals. The hypothalamus produces gonadotropin-releasing hormone (GnRH). The anterior portion of the pituitary gland produces luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone.
posterior pituitary gland
Gonadal hormones are those hormones that are actually released from the gonads (ex. estrogen, testosterone). Gonadotropins are hormones that CAUSE the release of gonadal hormones, gonadotropins are released from the anterior pituitary gland(tropin means "releasing" so gonadotropin is a gonad hormone releasing hormone) an example of this would be FSH-- follicle stimulating hormone.
Luteinizing hormone (LH) regulation primarily occurs through the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-releasing hormone (GnRH) released from the hypothalamus stimulates the pituitary gland to secrete LH. The levels of LH are further regulated by feedback from sex hormones such as estrogen and testosterone, which inhibit or stimulate GnRH and LH production depending on the physiological context, such as during the menstrual cycle or spermatogenesis. Additionally, factors like stress, nutrition, and overall health can also influence LH levels.
Progesterone plays a crucial role in the feedback mechanism of the menstrual cycle and pregnancy. It is primarily involved in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis by exerting negative feedback on the hypothalamus and pituitary gland, inhibiting the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH). This helps to maintain hormonal balance and prevent the premature release of eggs. During pregnancy, elevated progesterone levels support the uterine lining and inhibit uterine contractions, further ensuring a stable environment for fetal development.
Amenorrhea in pregnancy is primarily caused by the hormonal changes that occur after conception. The fertilized egg releases human chorionic gonadotropin (hCG), which signals the corpus luteum to continue producing progesterone and estrogen, hormones that help maintain the uterine lining and prevent menstruation. Additionally, increased levels of these hormones suppress the hypothalamic-pituitary-gonadal axis, inhibiting the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are essential for the menstrual cycle. This hormonal interplay effectively halts menstruation during pregnancy.
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No. The gonads are drained by the gonadal veins. The left gonadal vein empties into the left renal vein (and further into the inferior vena cava) whereas the right gonadal vein empties directly into the inferior vena cava.
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gonadal arteries
The most important determinant of the onset of puberty is the activation of the hypothalamic-pituitary-gonadal (HPG) axis. This hormonal axis becomes active due to changes in the levels of hormones such as GnRH, LH, and FSH, which in turn trigger the physical changes associated with puberty. Genes, nutrition, and environmental factors can also influence the timing of puberty onset.
The gonadal artery supplies blood to the gonads, which are the ovaries in females and the testes in males. In females, it branches from the abdominal aorta and provides oxygenated blood to the ovaries, while in males, it serves the testes. The gonadal arteries are crucial for supporting reproductive functions by delivering essential nutrients and oxygen to these organs.
In either case there is a bed of veins called the pampiniform plexus which directly drain the organs blood supply. The plexus then drains into discreet veins; from the ovaries, the ovarian veins and from the testes, the testicular veins. These discreet veins connect directly to the inferior vena cava.