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As fever is abnormally high body temperature, pathogens with strict temperature preferences may be hindered. Fever also speeds up immunological reactions as it enhances leukocyte phagocytosis, decreases the effects of the pathogens' endotoxins, and increases the proliferation of T cells. In addition, fever causes the liver and spleen to take up iron and zinc that are needed by the pathogens and it increases metabolic rate to speed up tissue repair.

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