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Her , here are a few examples. When the stomach is empty it's epithelium cells of its wall , release a hormone called Ghrelin , the release of ghrelin is proportional to the emptiness of the stomach. It is also known that Adipose cells ( FAT CELLS) release Leptin , leptin is involved in appetite, high levels of leptin reduce hunger. Insulin is also released from the pancreas. Another substance known to be involved is Glucose , low levels of glucose signal to the brain that we are hungry. Most of the chemicals i have mentioned travel through the blood stream to the Hypothalmus in the frontal lobe of the brain. Hope this gives you a littles insight into some of the Mechanisms ORCA-93 :)

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