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Antibodies (Abs), T cell receptors (TCRs) and MHC molecules are all involved in the adaptive immune response. All 3 of these (Abs, TCRs and MHCs) have a range of diversity of structure and are composed of different chains.

In most animals (including humans) antibodies are composed of 2 heavy chains and 2 light chains, each of which has constant and variable regions. This is very similar to a T cell receptor, which is composed of an α (alpha) and β (beta) chain - which have a contant and variable region.

In both cases, it is the variable region(s) which determines what the antibody or the T cell receptor can bind to. This is very important for their function.

T cell receptors (TCRs) and antibodies (Abs) are also similar in that their genes are combined and spliced in different ways to create diversity. It is important that both TCRs and Abs be able to recognise may different things.

MHC molecules are responsible for presenting antigens to T cell receptors. Once again, they are composed of an α (alpha) and β (beta) chain, which are different depending on whether they are MHC I or MHC II.

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