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Red blood cells (RBCs) are primarily formed in the bone marrow through a process called erythropoiesis. This process begins with hematopoietic stem cells, which differentiate into erythroid progenitor cells and eventually mature into reticulocytes, the precursor to mature RBCs. The hormone erythropoietin, produced by the kidneys in response to low oxygen levels, stimulates this production. Once released into the bloodstream, reticulocytes mature into fully functional red blood cells within a day or two.

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