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this is a very complicated and divers question. a disease is your body going out of it's equilibrium. this can be a cause of many events. the most common of which are pathogens, autoimmune problems and tumors. if we take the autoimmune issue from the answer (since its a situation in which the white blood cells are not working properly) we are left with pathogens (virus, bacteria, parasite, trauma) and tumor. to each type of pathogen or tumor there are different cells and singles that might be involve. but as a general principle, when a change in our body accrues it will stimulate the surrounding tissue and white blood cells that are in contact with the stimuli to release substances that will cause more white blood cells to arrive to the area, get activated and swallow and digest the stimuli or at least block it from spreading. also this process will make the bone marrow produce more white blood cells (leukocytes) and some of the leukocytes will duplicate (cloning). this process is called an inflammation and it is accompanied but other symptoms like fever and swelling that are either a result of the changes your body is going throu or a means to help your body to fight the disease.

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