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What is the purpose of cholinergic stimulants?
Cholinergic drugs are used for a variety of purposes, including the treatment of myasthenia gravis and during anesthesia.
What is cholinergic and anti cholinergic drugs?
Cholinergic drugs are used for urinary retention, myasthenia gravis, glaucoma. Cholinergic drugs act like the neurotransmitter ACh (acetylcholine). Anti Cholinergic (also called Cholinergic blocking) drugs block the action of the ACh. Anti Cholinergic drugs are used foe pylorospasm & peptic ulcers, bladder overactivity, parkinson's disease
How do indirect choligenic work?
Indirect cholinergic drugs work by inhibiting the enzyme acetylcholinesterase, which is responsible for breaking down acetylcholine in the body. By inhibiting this enzyme, indirect cholinergic drugs increase the levels of acetylcholine available in the nervous system, leading to prolonged cholinergic effects. This can be useful in conditions such as myasthenia gravis or Alzheimer's disease.
What drugs have interactions with cholinergic stimulants?
Certain antibiotics, especially neomycin, streptomycin, and kanamycin, can exacerbate the effects of some cholinergic stimulants. These antibiotics should be used with caution by people with myasthenia gravis.
What effects do cholinergic drugs produce?
Cholinergic drugs produce the same effects as acetylcholine. Acetylcholine is the most common neurohormone of the parasympathetic nervous system, the part of the peripheral nervous system responsible for the every day work of the body.
What are the drugs contraindicated in myasthenia gravis?
all mycin antibiotics except for erythromycin
Is a blepharectomy indicated in patients with ocular myasthenia gravis?
A blepharectomy is surgical removal of the eyelid. Ocular myasthenia gravis is treated with immunosuppressive drugs and low dose alternate day treatment with prednisone.
What are cholinergic stimulants?
they stimulate the action of ACh at post ganglionic muscarinic receptors.
Why aminoglycosides cause weakness in myasthenia gravis?
Aminoglycosides inhibit the release of acetylcholine from the motor nerve. Myestenia gravis patients are more susceptible to this effect. So these drugs are to be avoided in myestenia gravis patients.
What is anticholinesterase?
An anticholinesterase is an agent which inhibits the activity of cholinesterase.
What is treatment for myasthenia gravis?
MG treatments are practical rather than curative and include cholinesterase inhibitors, thymectomy, corticosteroids, immunosuppressant drugs, plasma exchange, intravenous immune globulin.
What is the difference between direct acting and indirect acting cholinergic drugs?
Direct acting cholinergic drugs directly bind to and activate cholinergic receptors, while indirect acting cholinergic drugs increase cholinergic activity by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine. Direct acting drugs include bethanechol and pilocarpine, while indirect acting drugs include donepezil and physostigmine.
