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During World War II, scarlet fever could be deadly due to a combination of factors including overcrowded living conditions, poor sanitation, and limited access to medical care in war-torn regions. The disease, caused by the bacterium Streptococcus pyogenes, can lead to severe complications such as rheumatic fever or kidney damage if left untreated. Additionally, antibiotics like penicillin, which became widely available after the war, were not commonly used during the early years of the war, making effective treatment difficult. The combination of these factors allowed scarlet fever to contribute to mortality rates in affected populations.

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