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generally there are special receptors to identify changes in blood pressure.there are osmo receptors and baro receptors present in blood vessels.these sense the changes in blood volume and pressure and pass on information to special centres .

when venous blood flow passes through kidneys these sense the changes in blood volume and pressure.when there is change in blood volume or pressure they release special substance called "RENIN".this renin is released special" JUXTRA GLOMERULAR APPARATUS".

juxtra glomerular apparatus;it includes 3 imp areas.

in afferent arteriole cells called JUXTRA GLOMERULAR CELLS

proximal portion of distal convoluted tubule contains MACULA DENSA.

cells called POLIKISSEN CELLS OR LACIS CELLS.

Renin acts on its substate called angiotensinogen[which is a protein synthesized by liver].then it forms angiotensin1.this reacts with enzyme called angiotensinogen converting factor and forms angiotensin2.this acts on adrenal gland and this release aldosteron which acts on renal tubules and absorb Na+ and also release antidiuretic harmone which absorbs water in renal tubules and effects blood volume and blood pressure.this is sensed by baroreceptors and these send information to higher centres and these higher centers present in medulla send impulses to heart and blood vessels to dilate or contract .thus as a result due to dilation blood pressure decreases or due to contraction bp increases.due to absorption of water blood volume increases or decreases.

THUS KIDNEYS EITHER DIRECTLY AND INDIRECTLY ACT ON HEART TO INFLUENCE BLOOD BP AND VOLUME.

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Aldesterone


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