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For bacterial pinkeye, the most common treatment is application of antibiotics or sulfonamides to the affected eye as ointments, powders or sprays; preferable, with treatment made twice a day. Foreign protein therapy, which is the subQ or IM injection of such things as sterile milk, has been used to treat pinkeye for years, but its value is difficult to establish. Cortisone is sometimes combined with antibiotics and injected under the covering (at the outer edge) of the eyeball. The cortisone helps with reducing inflammation and pain and also lessens the tears. Recovery speeds up if the eye is covered by a patch, or if the animal is confined to a dark barn. Protecting the cornea by suturing the eyelids together, by using adhesive patches, or by using an ocular insert (resembling a soft contact lens; developed by researchers at the University of Illinois) is indicated if there is severe corneal damage.

For viral pinkeye, this can only be prevented by vaccinations prior to the onset of the disease. The herd should not be vaccinated once the disease appears, nor should pregnant cows be vaccinated. Viral pinkeye is caused by IBR or Infectious Bovine Rhinotracheitis. Affected animals should be quarantined from the rest of the herd. Treatment for IBR is seldom of any value since there is no known treatment yet available for IBR, though antibiotics sometime help reduce secondary bacterial infection.

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