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In manual ventilation you can increase the PaO2 by hyperventilating the patient, by increasing the respiratory rate and/or by increasing the volume of air that you deliver to the patient. If using a BVM for example, compressing the bag faster and/or harder will increase the arterial oxygen pressure, but there is a limit to what you can do with manual ventilation. Perfusion in the lungs has a major impact on PaO2. Also, the blood chenistry (anemia or CO2 poisoning) for example will dramatically decrease the PaO2. Sometimes no matter how much you hyperventilate the person, low PaO2 can't be corrected.

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