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Cancer of the duodenum is best treated by surgical removal. A piece of the intestine containing the cancer is removed. Lymph nodes near the site of cancer are removed and checked for spread of cancer.

There may be cells of the cancer that are invisible to the surgeon that stay in the body after the surgery. These cells can grow into new tumors in months to years.

Chemotherapy given once a person has healed from surgery may keep those invisible cancer cells from growing in the future. Chemotherapy may be also be helpful if a person cannot have surgery for cancer (for example, a person's heart doctor thinks surgery would be very dangerous).

Radiation is another way to control cancer. The decision to use it depends on many factors.

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