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Yes, LSD exerts it's effects by affecting neurons. Primarily, it binds to 5-HT2A receptors, and thus mimics serotonin in some respects (but certainly not all, which accounts for it's low toxicity compared to the active dose). It also binds to other receptors, such as adrenergic and dopamine receptors, but it's psychedelic effects are due to the serotonergic properties.

It is important to note that despite it's effects on neurons, it has not been demonstrated to cause neurotoxicity. Thus, contrary to popular belief, it generally is harmless to neurons in all but the highest doses (many thousands of times as an average dose).

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13y ago

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