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Myosin light-chain kinase?
Myosin light-chain kinase (MLCK) is an enzyme that phosphorylates the regulatory light chain of myosin, leading to muscle contraction in smooth muscle cells. It plays a crucial role in regulating various cellular processes such as cell migration, cytokinesis, and smooth muscle contraction by modulating the activity of myosin. Dysregulation of MLCK activity has been linked to diseases such as asthma, hypertension, and certain types of cancer.
What does calcium bind to in smooth muscle contraction?
Calcium binds to the messenger protein Calmodulin. The calcium-calmodulin complex then activates myosin light chain kinase (MLCK), which phosphorylates myosin to allow it to bind to actin - producing contraction.
What protein makes up the thick filaments of myofibrils?
Myosin makes up the THICK filaments, and actin makes up the thin filaments of myofibrils.
What are the proteins are involved in muscle contraction?
Actin and myosin
What are the thick protein filaments in the cell made of?
The thick protein filaments in a cell are primarily made of a protein called myosin. Myosin filaments are involved in muscle contraction and various other cellular processes such as cell motility and cytokinesis.
What is the function of myosin?
Myosin is responsible for actin-based muscular mobility/contraction.
Binding of the myosin heads sequentially prevents what?
myosin crossbridge binding
The thick filaments of muscle fibers are composed of what?
Myosin
What does the release of ADP and P from the myosin head cause?
The release of ADP and P from the myosin heads causes the myosin heads to change shape.
What substances causes the myosin head to change shape?
ATP (adenosine triphosphate) is the main substance that causes the myosin head to change shape during muscle contraction. When ATP binds to the myosin head, it energizes the myosin molecule and allows it to detach from actin, resetting the myosin head for the next contraction cycle.
How do proteins actin and myosin interact to make a muscle contract?
Myosin and Actin
What acts as ATPase during the contraction cycle of muscle?
myosin cross-bridges
